Peer-reviewed veterinary case report
Early itching and inflammation in dog skin with atopic dermatitis
By Olivry, Thierry et al.·Published in The Journal of investigative dermatology·2016·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy) showed increased itching and inflammation after being exposed to house dust mites. Researchers took skin samples from these dogs at different times to study the immune response and found that certain proteins linked to itching and inflammation were significantly elevated. This suggests that the dogs' immune systems were reacting strongly to the allergens. The findings help in understanding how to develop new treatments for dogs suffering from this condition, which could lead to better management of their symptoms.
People also search for: dog itching treatment · atopic dermatitis in dogs · house dust mites allergy in dogs
Abstract
Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. To characterize inflammatory events occurring during early experimental acute AD lesions, biopsy samples were collected 6, 24, and 48 hours after epicutaneous application of Dermatophagoides farinae house dust mites to sensitized atopic dogs. The skin transcriptome was assessed using a dog-specific microarray and quantitative PCR. Acute canine AD skin lesions had a significant up-regulation of genes encoding T helper (Th) 2 (e.g., IL4, IL5, IL13, IL31, and IL33), Th9 (IL9), and Th22 (IL22) cytokines as well as Th2-promoting chemokines such as CCL5 and CCL17. Proinflammatory (e.g., IL6, LTB, and IL18) cytokines were also up-regulated. Other known pruritogenic pathways were also activated: there was significant up-regulation of genes encoding proteases cathepsin S (CTSS), mast cell chymase (CMA1), tryptase (TPS1) and mastin, neuromedin-B (NMB), nerve growth factor (NGF), and leukotriene-synthesis enzymes (ALOX5, ALOX5AP, and LTA4H). Experimental acute canine house dust mite-induced AD lesions exhibit an activation of innate and adaptive immune responses and pruritogenic pathways similar to those seen in humans with acute AD, thereby validating this model to test innovative therapeutics modalities for this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27342734/