Peer-reviewed veterinary case report
Early-Life Gut Dysbiosis: A Driver of Later-Life Fibrosis?
- Journal:
- The Journal of investigative dermatology
- Year:
- 2017
- Authors:
- Ho, Karen J & Varga, John
- Affiliation:
- Northwestern University · United States
Abstract
Using a novel mouse model of scleroderma induced by immunization with topoisomerase-I peptide-loaded dendritic cells, Mehta et al. found that early-life antibiotic exposure resulted in increased later-life fibrosis in the skin and lungs. These observations advance the novel concept that gut microbiome alterations caused by early-life exposures may contribute to scleroderma pathogenesis, and warrant in-depth characterization and validation in complementary disease models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29055411/