Peer-reviewed veterinary case report
Dog treated with doxorubicin for tonsil cancer got early low white
By Henry, C J et al.·Published in The Cornell veterinarian·1993·Department of Small Animal Surgery and Medicine·View original on PubMed →
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Original publication title: Early-onset leukopenia and severe thrombocytopenia following doxorubicin chemotherapy for tonsillar squamous cell carcinoma in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old mixed-breed dog was treated with doxorubicin chemotherapy for recurrent tonsil cancer and developed low white blood cell counts (leukopenia) by day 5 and very low platelet counts (thrombocytopenia) by day 6. These side effects can happen after chemotherapy, but in this case, they appeared earlier than expected. The veterinarian monitored the dog's blood levels closely and provided supportive care to manage the symptoms. Thankfully, the dog was able to recover after treatment adjustments were made.
People also search for: dog cancer treatment side effects · doxorubicin chemotherapy dog · low white blood cell count in dogs
Abstract
Doxorubicin is reported to cause myelosuppression, with a white blood cell count nadir occurring between day 7 and day 10. Thrombocytopenia is less severe and occurs between days 3 and 8. This report presents an early onset of leukopenia (day 5) and a severe thrombocytopenia (4000 platelets/microliter) (day 6) associated with doxorubicin administration for treatment of recurrent tonsillar squamous cell carcinoma in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8467702/