Peer-reviewed veterinary case report
Early results of polydioxanone mesh in breast implant surgery
By Sulkar RS et al.·2026·From the Perelman School of Medicine at the University of Pennsylvania, United States·View original on Europe PMC →
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Original publication title: Early Use and Outcomes of Polydioxanone Mesh in Implant-based Breast Reconstruction.
Plain-English summary
This study looked at how well a synthetic material called polydioxanone (PDO) mesh works in breast reconstruction after mastectomy, especially since traditional options can have issues like high infection rates and costs. Researchers tracked patients who had this mesh used during their implant-based breast reconstruction, either when placing a tissue expander or a permanent implant. They found that the success rate for using the PDO mesh was very high, with 97.2% success when used with tissue expanders and 96.9% with permanent implants. While there were some complications like infections and fluid buildup, there were no serious medical issues reported. Overall, the use of PDO mesh showed good safety and effectiveness in this study.
Abstract
<h4>Background</h4>As the diagnosis of breast cancer has increased during the past 2 decades, so too has the number of resection procedures, including mastectomies. Of the available reconstructive options postmastectomy, implant-based breast reconstruction (IBBR) predominates. Biologic scaffolds, such as human acellular dermal matrices, are routinely used to support tissue expanders and implants. However, human acellular dermal matrices have several limitations, including high infection rates, high cost, and supply concerns. Synthetic scaffolds address some of these concerns, though they differ significantly in time to resorption. In this study, we reported data from IBBR using polydioxanone (PDO) mesh.<h4>Methods</h4>This prospective, multisite, observational registry study evaluated the use of PDO mesh (DuraSorb) implanted during IBBR, including 2-stage and direct-to-implant procedures. Based on the timing of PDO mesh placement, success was defined as the placement of a permanent implant or completion of reconstruction in the absence of major adverse events requiring expander or permanent implant removal. Adverse events were also recorded.<h4>Results</h4>Procedural success with PDO mesh was 97.2% (n = 71), 96.9% (n = 32), and 75% (n = 4) when implanted at the time of the tissue expander, permanent implant placement, and direct-to-implant procedures, respectively. The incidence of infection, skin flap necrosis, and seroma requiring drainage was 6.5%, 12.2%, and 10.3% of breasts, respectively. No medical complications (deep vein thrombosis, pulmonary embolism, cardiac events, acute renal failure, difficulty weaning from the ventilator) were reported.<h4>Conclusions</h4>IBBR using PDO mesh demonstrated favorable safety and performance outcomes in this observational study.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41550079