Peer-reviewed veterinary case report
Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs.
- Journal:
- Muscle & nerve
- Year:
- 2010
- Authors:
- Tegeler, Christopher J et al.
- Affiliation:
- Wake Forest University Health Sciences · United States
- Species:
- dog
Abstract
We tested the hypothesis that eccentric contractions (ECCs) rapidly induce greater-than-normal isometric torque drop in dystrophin-deficient golden retriever muscular dystrophy (GRMD) muscles. ECCs were imposed by forcibly stretching activated muscles. The results indicate that isometric torque drop was greater in GRMD versus controls (P < 0.0001). Our findings support the hypothesis that ECCs induce greater-than-normal isometric torque drop in GRMD muscles. The magnitude of ECC-induced isometric torque loss may be an ideal clinical endpoint in the GRMD model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20544944/