Peer-reviewed veterinary case report
Rat with pancreatic cancer in chest - what does it mean?
By Fujiwara C et al.Ā·2023Ā·The Institute of Environmental Toxicology, JapanĀ·View original on Europe PMC ā
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Original publication title: Ectopic pancreatic acinar cell carcinoma in the thoracic cavity of F344 rat.
- Species:
- rodent
Plain-English summary
This case report discusses a rare type of cancer found in a female Fischer rat. The cancer, called ectopic pancreatic acinar cell carcinoma, developed in an unusual location: the thoracic cavity, which is the area in the chest. Normally, pancreatic tissue can cause problems like inflammation or bleeding, but tumors from this tissue are very uncommon. In this case, the tumor cells had specific characteristics that identified them as pancreatic cells, and this is the first time such a tumor has been reported in this part of a rat's body.
Abstract
Ectopic pancreatic tissue can occasionally cause inflammation, hemorrhage, stenosis, and invagination, similar to normal pancreatic tissue; however, tumorigenesis is rare. This case report describes an ectopically observed pancreatic acinar cell carcinoma in the thoracic cavity of a female Fischer (F344/DuCrlCrlj) rat. Histopathologically, polygonal tumor cells with periodic acid-Schiff-positive cytoplasmic eosinophilic granules showed solid proliferation and infrequently formed acinus-like structures. Immunohistochemically, the tumor cells were positive for cytokeratin, trypsin, and human B-cell leukemia/lymphoma 10, which specifically reacted with pancreatic acinar cells, and negative for vimentin and human Ī±-smooth muscle actin. Ectopic pancreas develops in the submucosa of the gastrointestinal tract; however, there are few reports of its development and neoplasia in the thoracic cavity. To the best of our knowledge, this is the first report of ectopic pancreatic acinar cell carcinoma in the thoracic cavity of a rat.
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Search related cases āOriginal publication on Europe PMC: https://europepmc.org/article/MED/37101959