Peer-reviewed veterinary case report
Effect of a contralateral lesion on neurological recovery from stroke in rats.
- Journal:
- Restorative neurology and neuroscience
- Year:
- 2012
- Authors:
- Sun, Fen et al.
- Affiliation:
- Department of Pharmacology and Neuroscience · United States
- Species:
- rodent
Abstract
PURPOSE: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. METHODS: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. RESULTS: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. CONCLUSIONS: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22868223/