Peer-reviewed veterinary case report
Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis.
- Journal:
- Vascular pharmacology
- Year:
- 2007
- Authors:
- Singh, Shashank Kumar et al.
- Affiliation:
- Pharmacology Division · India
- Species:
- rodent
Abstract
Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto beta-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel+bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto beta-boswellic acids (10 mg/kg/d) inhibited the Matrigel+bFGF-induced angiogenesis significantly (P<0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17257903/