Peer-reviewed veterinary case report
Effect of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats.
- Journal:
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- Year:
- 2013
- Authors:
- Liu, Cun-Zhi et al.
- Affiliation:
- Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University · China
- Species:
- rodent
Abstract
Redox effector factor (Ref-1) is a sensitive marker for oxidative cellular injury. The aim of this study was to investigate the effects of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats. The rats with reference memory impairment were randomly allocated to three groups: impaired group, acupuncture group and placebo acupuncture group. Moreover, normal group and sham-operated group were set as control groups. Morris water maze test showed that cerebral multi-infarction rats did not present significant changes in spatial working memory performance. Further investigation by immunohistochemistry revealed that acupunctural treatment significantly increased the expression of Ref-1 in the hippocampus of the impaired rats. These findings suggested that the spatial working memory was unaffected in the cerebral multi-infarction rats although spatial reference memory deficits were detected in our previous study; in addition, acupuncture could increase the Ref-1 expression, consequently exerting the anti-oxidant effects.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22391677/