Peer-reviewed veterinary case report
How propofol injection speed affects anesthesia dose in male cats
By Oliveira, Renato Ls et al.·Published in Journal of feline medicine and surgery·2018·Department of Medicine and Surgery, Brazil·View original on PubMed →
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Original publication title: Effect of administration rate on propofol requirement in cats.
- Species:
- cat
Plain-English summary
A group of 40 male cats, around 1.5 years old, were given anesthesia for a neutering procedure. They received a sedative along with either methadone or saline before being put under anesthesia with propofol. The results showed that the cats that received methadone and had the propofol administered quickly needed less of the drug to achieve anesthesia compared to the other groups. However, the sedation from the premedication was not sufficient, and the cats showed excitement during the induction process. Using methadone with a faster propofol administration rate helped make the anesthesia process smoother.
People also search for: cat anesthesia methadone · why is my cat excited during anesthesia · propofol dosage for cats
Abstract
Objectives The objective of this study was to determine the effect of administration rate on propofol dose for induction of anesthesia and the effect of methadone on this dose. Methods This was a prospective, randomized, blinded clinical study. Forty male cats (mean ± SD age 1.5 ± 0.8 years) were admitted for orchiectomy. Cats were randomly allocated to receive acepromazine (0.05 mg/kg) with either methadone (MET; 0.3 mg/kg) or saline (SAL; 0.03 ml/kg). Each premedication group then received anesthetic induction with propofol at 5 (F) or 1.5 mg/kg/min (S), resulting in the following four groups: MET-F, SAL-F, MET-S and SAL-S. Sedation scores were assigned at 15 and 30 mins after premedication using a simple descriptive scale (SDS) and a visual analog scale (VAS). After assignment of sedation scores, respiratory frequency ( f) was recorded, and anesthetic induction began and was continued until cats lost their palpebral reflexes and jaw tone, and the eye globe rotated ventromedially. The time for induction and the total amount of propofol needed was recorded, and intubation was then performed. After intubation, fwas also recorded. Results SDS and VAS sedation scores were low at 15 and 30 mins after premedication. There was no significant difference in sedation scores by time or between the groups at any time on any scale. The amount of propofol needed to achieve anesthetic induction was 5.3 ± 1.1 mg/kg in group MET-F, which was statistically lower when compared with the other three groups, which demonstrated no difference among them. Conclusions and relevance Premedication with acepromazine and methadone was not able to produce adequate sedation in healthy cats. The slow induction rate is not adequate for use in cats considering that all of the animals demonstrated excitement during anesthetic induction. The fast administration rate was able to produce adequate induction of anesthesia and reduce the amount of propofol needed to achieve intubation only when using methadone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29172963/