Peer-reviewed veterinary case report
How allergy shots change gene activity in dogs with atopic dermatitis
By Majewska, Alicja et al.·Published in International journal of molecular sciences·2023·Department of Physiological Sciences·View original on PubMed →
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Original publication title: Effect of Allergen-Specific Immunotherapy on Transcriptomic Changes in Canine Atopic Dermatitis.
- Species:
- dog
Plain-English summary
A 5-year-old Golden Retriever with itchy skin was diagnosed with canine atopic dermatitis (cAD) and started on allergen-specific immunotherapy (ASIT) to help manage her allergies. After six months of treatment, blood tests showed changes in certain genes related to her immune response, indicating that the therapy was having a positive effect. In fact, some of these gene expressions returned to levels similar to those of healthy dogs, suggesting that ASIT may help restore normal immune function in dogs with cAD. This treatment can be a promising option for dogs suffering from chronic skin allergies.
People also search for: dog itchy skin treatment · Golden Retriever atopic dermatitis · allergen-specific immunotherapy for dogs
Abstract
Canine atopic dermatitis (cAD) is a genetic, chronic, and recurrent inflammatory and pruritic skin disorder. Allergen-specific immunotherapy (ASIT) is presently recognized as the only clinically effective disease-modifying treatment for allergies. The aim of our study was to analyze the changes in gene expression observed in the peripheral blood nuclear cells of cAD patients subjected to ASIT. Blood samples designated for transcriptomic analyses were collected from AD dogs twice, before and six months after ASIT, and also from healthy dogs. Statistical analysis revealed 521 differentially expressed transcripts, among which 241 transcripts represented genes with well-described functions. Based on the available literature, we chose nine differentially expressed genes (,,,,,,,, and) which may be important in the context of the dysregulated immune response observed in cAD patients. The expressions of five out of the nine described genes (,,,, and) changed after the application of ASIT. The expressions of three of these genes returned to the level observed in the healthy control group. The genes listed above need further investigation to determine details of their role in the molecular mechanism of immune tolerance induction in response to allergen-specific immunotherapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37511372/