Peer-reviewed veterinary case report
Effect of atorvastatin on dendritic cells of tubulointerstitium in diabetic rats.
- Journal:
- BMB reports
- Year:
- 2010
- Authors:
- Tu, Yafang et al.
- Affiliation:
- Nephrology Department · China
- Species:
- rodent
Abstract
Inflammatory reactology has become increasingly important in diabetic kidney disease. In this study, we estabilished STZ-induced diabetic rat model to investigate whether dendritic cells (DCs) mediated tubulointerstitial damages, and whether the effects by DCs were mediated by P-selectin expression and can be inhibited by atorvastatin. The study demonstrated that there was an accumulation of DCs in diabetic rats mediated by P-selectin. It also showed the accumulation of DCs and expression of P-selectin was closely correlated with the degree of renal tubulointerstitial injury. These effects were markedly attenuated by atorvastatin. Thus, DCs play a role in tubulointerstitial damages, atorvasttin can prevent renal tubulointerstitium from damage by inhibiting the P-selectin expression and DCs migration.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20356459/