Peer-reviewed veterinary case report
How calcitriol affects immune response in critically ill dogs
By Jaffey, J A et al.·Published in Veterinary journal (London, England : 1997)·2018·University of Missouri, United States·View original on PubMed →
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Original publication title: Effect of calcitriol on in vitro whole blood cytokine production in critically ill dogs.
- Species:
- dog
Plain-English summary
Twelve critically ill dogs were treated with calcitriol, a form of vitamin D, to see if it could help reduce inflammation in their bodies. The dogs were in a veterinary intensive care unit and had their blood tested before and after treatment. The results showed that calcitriol increased the production of a helpful protein (IL-10) that fights inflammation and decreased another protein (TNF-α) that causes inflammation. However, there was no difference in the overall immune response between dogs that survived and those that did not after their treatment.
People also search for: dog critical care treatment · vitamin D for sick dogs · inflammation in dogs treatment
Abstract
Hypovitaminosis D has been identified as a predictor of mortality in human beings, dogs, cats and foals. However, the immunomodulatory effects of vitamin D in critically ill dogs has not been evaluated. The aim of this study was to evaluate the effect of calcitriol on cytokine production from whole blood collected from critically ill dogs in vitro. Twelve critically ill dogs admitted to a veterinary intensive care unit (ICU) were enrolled in a prospective cohort study. Whole blood from these dogs was incubated with calcitriol (2×10M) or ethanol (control) for 24h. Subsequent to this incubation, lipopolysaccharide (LPS)-stimulated whole blood production of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-10 were measured using a canine-specific multiplex assay. Calcitriol significantly increased LPS-stimulated whole blood production of IL-10 and decreased TNF-α production without significantly altering IL-6 production. There was no significant difference in whole blood cytokine production capacity between survivors and non-survivors at the time of discharge from the ICU or 30days after discharge. These data suggests that calcitriol induces an anti-inflammatory phenotype in vitro in whole blood from critically ill dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29871746/