Peer-reviewed veterinary case report
How CBD affects inflammation in dog blood samples
By Enrico Gugliandolo et al.·Published in Veterinary Sciences·2021·Department of Veterinary Science, University of Messina, 98166 Messina, Italy, CH·View original on DOAJ →
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Original publication title: Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood
- Species:
- dog
Plain-English summary
A study found that cannabidiol (CBD) may help reduce inflammation in dogs. Researchers tested CBD on blood samples from healthy dogs that were stimulated to create an inflammatory response. They noticed that CBD lowered levels of certain inflammatory markers, suggesting it could help manage inflammation in dogs. While this research is still in early stages, it shows promise for CBD as a potential treatment for inflammatory conditions in pets.
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Abstract
The use of cannabidiol (CBD) for animal species is an area of growing interest, for example for its anti-inflammatory and immuno-modulating properties, even though all of its biological effects are still not fully understood, especially in veterinary medicine. Therefore, the aim of this study was to investigate the anti-inflammatory and immuno-modulating properties of CBD for the first time directly in canine inflammatory response. We used an ex vivo model of LPS-stimulated whole dog blood. We stimulated the whole blood from healthy dogs with LPS 100 ng/mL for 24 h in the presence or not of CBD 50 and 100 μg/mL. We observed a reduction in IL-6 and TNF-α production from the group treated with CBD, but non-altered IL-10 levels. Moreover, we also observed from the CBD-treated group a reduction in Nf-κB and COX-2 expression. In conclusion, we demonstrated for the first time the anti-inflammatory and immuno-modulating properties of CBD directly in dogs’ immune cells, using a canine ex vivo inflammatory model. The results obtained from these studies encourage further studies to better understand the possible therapeutic role of CBD in veterinary medicine.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/vetsci8090185