Peer-reviewed veterinary case report
Chloroquine effects on feline infectious peritonitis virus in cats
By Takano, Tomomi et al.·Published in Antiviral research·2013·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo.
- Species:
- cat
Plain-English summary
A group of cats with feline infectious peritonitis (FIP), a serious disease caused by a coronavirus, was treated with chloroquine to see if it could help. The cats that received chloroquine showed better clinical signs compared to those that did not receive the treatment. However, there was a concerning increase in liver enzyme levels in the chloroquine-treated cats, indicating potential side effects. More research is needed to explore the best ways to use chloroquine, possibly in combination with other treatments, to effectively manage FIP.
People also search for: cat FIP treatment · chloroquine for cats · feline infectious peritonitis symptoms
Abstract
Feline infectious peritonitis (FIP) is a feline coronavirus-induced fatal disease in domestic and wild cats. Several studies have investigated potential treatments for FIP. However, there have been no reports on agents that have exhibited a therapeutic effect. Recently, chloroquine has been reported to antiviral effect. We investigated whether chloroquine can be used to treat FIP in vitro and in vivo. It was demonstrated that chloroquine has inhibitory effect against the replication of FIPV and anti-inflammatory effect in vitro. In vivo study using cats with experimentally induced FIP, the clinical score of chloroquine-treatment groups were better than in chloroquine-untreated group. However, alanine aminotransferase levels increased in the chloroquine-treated groups. It will be necessary to further investigate the possibility of FIP treatment with a combination of chloroquine and other agents.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23648708/