Peer-reviewed veterinary case report
Effect of collagen I gel on apoptosis of rat hepatic stellate cells.
- Journal:
- Acta medica (Hradec Kralove)
- Year:
- 2013
- Authors:
- Bittnerová, Lenka et al.
- Affiliation:
- Department of Medical Biochemistry
- Species:
- rodent
Abstract
Activated hepatic stellate cells (HSC) are a major source offibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl4-damaged liver. We have found that type I collagen gel enhances HSC apoptosis regardless of the agent triggering this process.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24069661/