Effect of different diets on Tyrophagus putrescentiae population and amelioration of their immunological disorder by garlic.

Abstract

BACKGROUND: The storage mite, Tyrophagus putrescentiae, detected in the samples collected from stored products and house dust, is one of the major causes of allergic disorders. OBJECTIVE: The purpose of this study was to ameliorate the T. putrescentiae faeces allergic immunological disorder by garlic. METHODS: Albino experimental rats were classified into control, inhaled and treated groups. Mass rearing of T. putrescentiae on different diets, and ELISA of some cytokines and IgE techniques were used. RESULTS: The results obtained showed the highest population of T. putrescentiae reared in four from thirteen tested diets. In addition, significantly higher serum levels of INF-&#x3b3; and IgE were found in rats treated with faeces than the other groups; especially the garlic-treated group. In contrast, IL-4 was lower in faeces-treated rats than the others; however, the control group had the highest level of IL-4. Statistical analysis of data showed a significant difference between the garlic-treated group and either control or faeces-treated groups (P<0.05). CONCLUSIONS: The population of T. putrescentiae mites peaked in four from thirteen tested diets. The immunological disorder caused by repeated exposure to T. putrescentiae faeces might be modulated by garlic.