Peer-reviewed veterinary case report
Maropitant timing to stop vomiting from hydromorphone in dogs
By Hay Kraus, Bonnie LĀ·Published in Journal of the American Veterinary Medical AssociationĀ·2014Ā·Department of Veterinary Clinical SciencesĀ·View original on PubMed ā
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Original publication title: Effect of dosing interval on efficacy of maropitant for prevention of hydromorphone-induced vomiting and signs of nausea in dogs.
- Species:
- dog
Plain-English summary
Fifty dogs undergoing surgery were given a medication called maropitant to help prevent vomiting and nausea caused by another drug, hydromorphone. The study found that giving maropitant 15 to 30 minutes before hydromorphone significantly reduced vomiting, while nausea was only reduced when maropitant was given 60 minutes beforehand. This means that if your dog needs hydromorphone after surgery, timing the maropitant dose correctly can help keep them more comfortable and reduce the chances of vomiting.
People also search for: dog vomiting after surgery Ā· maropitant for dog nausea Ā· hydromorphone side effects in dogs
Abstract
OBJECTIVE: To evaluate the effect of dosing interval on the efficacy of maropitant for prevention of opioid-induced vomiting and signs of nausea in dogs. DESIGN: Randomized prospective clinical study. ANIMALS: 50 client-owned dogs that underwent an elective surgical procedure. Procedures: Dogs were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC), then hydromorphone (0.1 mg/kg [0.045 mg/lb], IM) at 0 (simultaneously; group 0; n = 10), 15 (group 15; 10), 30 (group 30; 10), 45 (group 45; 10), or 60 (group 60; 10) minutes later. Dogs were monitored for vomiting and signs of nausea for 30 minutes after hydromorphone administration. A historical control group of similar dogs (n = 9) that were administered hydromorphone (0.1 mg/kg, IM) but not maropitant served as the referent for comparison purposes. RESULTS: Vomiting was recorded for 6 dogs in group 0 and 2 dogs in group 15. Signs of nausea were recorded for 10 dogs in group 0, 9 dogs in group 15, 8 dogs in group 30, 6 dogs in group 45, and 1 dog in group 60. Compared with dogs in the historical control group, vomiting was significantly decreased and prevented when maropitant was administered 15 and 30 minutes, respectively, before hydromorphone; signs of nausea were significantly decreased only when maropitant was administered 60 minutes before hydromorphone. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that vomiting was significantly decreased and then prevented when maropitant was administered to dogs 15 and 30 minutes before hydromorphone. However, signs of nausea were significantly decreased only when the dosing interval was 60 minutes.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25313812/