Peer-reviewed veterinary case report
Esomeprazole effects on gut health in healthy dogs
By McAtee, Rae et al.·Published in Journal of veterinary internal medicine·2023·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Effect of esomeprazole with and without a probiotic on fecal dysbiosis, intestinal inflammation, and fecal short-chain fatty acid concentrations in healthy dogs.
- Species:
- dog
Plain-English summary
Eleven healthy dogs were given a medication called esomeprazole, which is often used to reduce stomach acid, to see if it caused any digestive issues like diarrhea or changes in gut bacteria. Some dogs received esomeprazole alone, while others received it with a probiotic to see if that would help. The study found that adding the probiotic did not significantly reduce the side effects of esomeprazole, such as diarrhea or vomiting. Overall, the probiotic did not seem to help with the digestive problems caused by the medication.
People also search for: dog diarrhea after medication · esomeprazole side effects in dogs · probiotic for dog digestive health
Abstract
BACKGROUND: Proton pump inhibitors can cause diarrhea and a transient increase in fecal dysbiosis index in dogs. It is unknown if concurrent probiotic administration mitigates these effects. OBJECTIVE/HYPOTHESIS: To assess the fecal Canine Microbial Dysbiosis Index (CMDI), fecal short chain fatty acid (SCFA), and fecal calprotectin concentrations in dogs administered esomeprazole with and without a probiotic. ANIMALS: Eleven healthy dogs. METHODS: Prospective, within-subjects before and after study. All dogs received 7-day courses of esomeprazole (1 mg/kg PO q 24h) alone followed by esomeprazole with a probiotic (15 billion CFU/kg), separated by a 4-week washout period. Data were compared between phases using mixed effects ANOVA or generalized estimating equations with post-hoc Holm adjustment for 2-way comparisons. RESULTS: Compared to baseline (mean CMDI -2.66, SD 3.04), fecal CMDI was not different with esomeprazole administration alone (mean CMDI -1.48, SD 3.32, P = .08), but there was a significant increase (Diff 3.05, 95% CI [1.37, 4.74], P < .001, Effect size 2.02) when esomeprazole and a probiotic were administered concurrently (mean CMDI 0.39, SD 2.83). CMDI was significantly higher when esomeprazole was administered with a probiotic than alone (Diff 1.87, 95% CI [0.19, 1.87], P = .02, Effect size 1.24). Fecal calprotectin and SCFA concentrations did not differ between phases. The occurrence of vomiting and diarrhea was not different from baseline when esomeprazole was administered alone (36%/27%) or with a probiotic (46%/9%). CONCLUSIONS AND CLINICAL IMPORTANCE: In healthy dogs, concurrent administration of a probiotic is unlikely to lessen adverse effects associated with esomeprazole administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37776099/