Peer-reviewed veterinary case report
Effect of Ewe Nutritional Restriction During Gestation on the Number of Sertoli Cells in the Offspring: A Meta-Analysis.
- Year:
- 2026
- Authors:
- Espinosa-Martínez MA et al.
- Affiliation:
- CENID Fisiología y Mejoramiento Animal-INIFAP
Abstract
Maternal nutrition during gestation critically influences foetal reproductive programming. To clarify inconsistent evidence, a meta-analysis was performed to assess the effect of maternal nutritional restriction on the number of Sertoli cells in ovine offspring. A systematic review in PubMed, Google Scholar, Scopus and Science Direct identified three studies (four comparisons; n = 52). Standardised mean differences (Hedges' g) were calculated using a random-effects model. The pooled effect was significant (g = -0.95, 95% CI: -1.49 to -0.41; p < 0.001), with no heterogeneity (I<sup>2</sup> = 0%) or publication bias (Egger's test p = 0.616). In conclusion, maternal undernutrition reduces Sertoli cell numbers by approximately one standard deviation.
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Search related cases →Original publication: https://europepmc.org/article/MED/41665278