Peer-reviewed veterinary case report
How hypothyroidism affects kidney filtration and creatinine in female
By Panciera, D L & Lefebvre, H P·Published in Journal of veterinary internal medicine·2009·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Effect of experimental hypothyroidism on glomerular filtration rate and plasma creatinine concentration in dogs.
- Species:
- dog
Plain-English summary
A group of 16 female dogs had their thyroid function altered to study how hypothyroidism affects kidney function. After inducing hypothyroidism in half of the dogs, researchers found that their kidney filtration rate was significantly lower compared to healthy dogs, even though their blood creatinine levels remained normal. This suggests that hypothyroidism can impair kidney function without showing typical signs in blood tests. It's important for veterinarians to evaluate kidney function directly in dogs with hypothyroidism to catch any potential issues early.
People also search for: dog hypothyroidism symptoms · kidney function tests in dogs · low creatinine levels in dogs
Abstract
BACKGROUND: Hypothyroidism affects renal function in a manner opposite the effects of hyperthyroidism. OBJECTIVE: To evaluate the effects of experimentally induced hypothyroidism on glomerular filtration rate (GFR) and basal plasma creatinine concentration in dogs. ANIMALS: Sixteen anestrous, female dogs. METHODS: Hypothyroidism was induced by administration of (131)I in 8 dogs, and 8 healthy euthyroid dogs acted as controls. Exogenous plasma creatinine clearance (an estimate of GFR) was measured in all dogs before (control period) and 43-50 weeks after induction of hypothyroidism (posttreatment period). Other pharmacokinetic parameters of creatinine were also determined. RESULTS: No significant difference was observed for basal plasma creatinine concentration and creatinine clearance between control and hypothyroid dogs in the control period. In the posttreatment period, mean + or - SD creatinine clearance in the hypothyroid group (2.13 + or - 0.48 mL/min/kg) was lower (P < .001) than that of the control group (3.20 + or - 0.42 mL/kg/min). Nevertheless, basal plasma creatinine concentrations were not significantly different between the hypothyroid and control groups (0.74 + or - 0.18 versus 0.70 + or - 0.08 mg/dL, respectively) because endogenous production of creatinine was decreased in hypothyroid dogs (22 + or - 3 versus 32 + or - 5 mg/kg/d, P=.001). CONCLUSION AND CLINICAL IMPORTANCE: Hypothyroidism causes a substantial decrease in GFR without altering plasma creatinine concentrations, indicating that GFR evaluation is needed to identify renal dysfunction in such patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19678885/