Peer-reviewed veterinary case report
Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats.
- Journal:
- Experimental diabetes research
- Year:
- 2009
- Authors:
- Morinaga, Hisayo et al.
- Affiliation:
- Central Pharmaceutical Research Institute · Japan
- Species:
- rodent
Abstract
Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19696902/