Peer-reviewed veterinary case report
Effect of fowl adenovirus-1 (IBH isolate) on humoral and cellular immune competency of broiler chicks.
- Journal:
- Comparative immunology, microbiology and infectious diseases
- Year:
- 2006
- Authors:
- Singh, Amarjit et al.
- Affiliation:
- Department of Veterinary Pathology · India
Abstract
Fowl adenovirus-1 (FAV-1), isolated from field outbreaks of inclusion body hepatitis (IBH), was administered orally to 3-week-old disease-free broiler chicks. Humoral immune competency was evaluated by determining the antibody response of infected chicks to sheep red blood cells (SRBC) and Brucella abortus. FAV-1 infection significantly decreased the antibody response of chicks to B. abortus (T-cell-independent antigen) by decreasing IgM responses, however, the decreased antibody response to SRBC (T-cell-dependent antigen) was statistically non-significant. Bursal index was also found lowered in infected chicks as compared to the control chicks. A significant decrease was seen in blastogenesis response of peripheral blood lymphocytes to phytohaemagglutinin (PHA-P) in FAV-1-infected chicks on 2 and 3 weeks post-infection (WPI). These results indicated that FAV-1 affects humoral as well as cellular immune competency of infected chicks.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17045338/