Peer-reviewed veterinary case report
Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches.
- Journal:
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
- Year:
- 2006
- Authors:
- Cho, Sun-A et al.
- Affiliation:
- Department of Laboratory Animal Medicine · South Korea
- Species:
- rodent
Abstract
The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 microg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16414253/