Peer-reviewed veterinary case report
Stem cell treatment for hip osteoarthritis in Presa Canario dogs
By Vilar, Jose M et al.·Published in BMC veterinary research·2016·Department of Animal Pathology, Spain·View original on PubMed →
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Original publication title: Effect of intraarticular inoculation of mesenchymal stem cells in dogs with hip osteoarthritis by means of objective force platform gait analysis: concordance with numeric subjective scoring scales.
- Species:
- dog
Plain-English summary
Ten Presa Canario dogs with hip osteoarthritis were treated with mesenchymal stem cells to help reduce their lameness. After six months, while the owners reported some improvement in their dogs' pain levels using pain scales, the objective measurements from a force platform showed that the dogs had returned to their original level of lameness. This suggests that relying solely on owner-reported pain scores may not accurately reflect the dogs' actual mobility and pain levels.
People also search for: Presa Canario hip osteoarthritis treatment · mesenchymal stem cells for dog arthritis · dog lameness improvement assessment
Abstract
BACKGROUND: Subjective pain assessment scales have been widely used for assessing lameness in response to pain, but the accuracy of these scales has been questioned. To assess scale accuracy, 10 lame, presa Canario dogs with osteoarthritis (OA) associated with bilateral hip dysplasia were first treated with mesenchymal stem cells. Then, potential lameness improvement was analyzed using two pain scales (Bioarth and visual analog scale). These data were compared with similar data collected using a force platform with the same animals during a period of 6 months after treatment. RESULTS: The F test for intraclass correlation showed that concordance in pain/lameness scores between the 2 measuring methodologies was not significant (P value ≥ 0.9213; 95 % confidence interval, -0.56, 0.11). Although subjective pain assessment showed improvement after 6 months, force platform data demonstrated those same animals had returned to the initial lameness state. CONCLUSION: Use of pain assessment scales to measure lameness associated with OA did not have great accuracy and concordance when compared with quantitative force platform gait analysis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27717361/