Peer-reviewed veterinary case report
Lidocaine reduces cough and heart rate changes during dog intubation
By Jolliffe, Colette T et al.·Published in Veterinary anaesthesia and analgesia·2007·Centre for Small Animal Studies, United Kingdom·View original on PubMed →
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Original publication title: Effect of intravenous lidocaine on heart rate, systolic arterial blood pressure and cough responses to endotracheal intubation in propofol-anaesthetized dogs.
- Species:
- dog
Plain-English summary
Eighty dogs were given either intravenous lidocaine or saline before being put under anesthesia with propofol for a procedure that required intubation. The goal was to see if lidocaine could reduce coughing and changes in heart rate and blood pressure during intubation. However, the study found that lidocaine did not affect the number or strength of coughs, nor did it change blood pressure compared to the saline group. Both groups experienced an increase in blood pressure after intubation, but there was no significant difference between the two treatments.
People also search for: dog cough after intubation · lidocaine for dogs anesthesia · propofol side effects in dogs
Abstract
OBJECTIVE: To evaluate the effect of intravenous lidocaine on coughing and variations in heart rate (HR) and systolic arterial pressure (SAP) at endotracheal intubation in propofol-anaesthetized dogs. STUDY DESIGN: Prospective, randomized, blinded clinical study. ANIMALS: Eighty dogs, ASA grades I/II. METHODS: Dogs were randomly assigned to one of two treatments, with dogs in the lidocaine group receiving 1 mg kg(-1) lidocaine intravenously and those in the saline group receiving 0.05 mL kg(-1) saline intravenously before induction of anaesthesia with up to 6.5 mg kg(-1) propofol intravenously. An electrocardiogram was recorded continuously. Heart rate was calculated and SAP (using Doppler ultrasonic flow detection) was recorded at the following time points: pre-treatment, following lidocaine or saline administration, before and after intubation. The occurrence, number and strength of coughs were recorded. Systolic arterial pressure and HR were compared using one-sample t-tests to examine whether SAP and HR changed with test drug administration or following intubation. The number of coughs was compared between groups using t-tests. A cross tabulation and chi-square or Fisher's exact test was used to compare proportions of dogs that coughed and intensity of coughing in each group. The level of significance was set at p < 0.05. RESULTS: Heart rate did not change in either group. Systolic arterial blood pressure increased following intubation in both the lidocaine (p = 0.003) and saline groups (p = 0.001). There was no difference in the increase in SAP or in the number or intensity of coughs at intubation between groups. CONCLUSIONS AND CLINICAL RELEVANCE: Intravenous lidocaine had no effect on the occurrence or intensity of coughing or on changes in SAP at endotracheal intubation in dogs anaesthetized with propofol. The use of 1 mg kg(-1) lidocaine intravenously before intubation in dogs to attenuate cough and the pressor response was not supported.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17490467/