Effect of Intravenous Small-Volume Hypertonic Sodium Bicarbonate, Sodium Chloride, and Glucose Solutions in Decreasing Plasma Potassium Concentration in Hyperkalemic Neonatal Calves with Diarrhea.

Abstract

BACKGROUND: Hyperkalemia is a frequently observed electrolyte imbalance in dehydrated neonatal diarrheic calves that can result in skeletal muscle weakness and life-threatening cardiac conduction abnormalities and arrhythmias. HYPOTHESIS: Intravenous administration of a small-volume hypertonic NaHCOsolution is clinically more effective in decreasing the plasma potassium concentration (cK) in hyperkalemic diarrheic calves than hypertonic NaCl or glucose solutions. ANIMALS: Twenty-two neonatal diarrheic calves with cK >5.8 mmol/L. METHODS: Prospective randomized clinical trial. Calves randomly received either 8.4% NaHCO(6.4 mL/kg BW; n = 7), 7.5% NaCl (5 mL/kg BW; n = 8), or 46.2% glucose (5 mL/kg BW; n = 7) IV over 5 minutes and were subsequently allowed to suckle 2 L of an electrolyte solution. Infusions with NaHCOand NaCl provided an identical sodium load of 6.4 mmol/kg BW. RESULTS: Hypertonic NaHCOinfusions produced an immediate and sustained decrease in plasma cK. Hypertonic glucose infusions resulted in marked hyperglycemia and hyperinsulinemia, but cK remained unchanged for 20 minutes. Between 30 and 120 minutes after initiation of treatment, the most marked decrements in cK from baseline occurred in group NaHCO, which were significantly (P < .05) larger during this period of time than in calves in group NaCl, but not group glucose. After 120 minutes, the mean decrease in cK from baseline was -26 &#xb1; 10%, -9 &#xb1; 8%, and -22 &#xb1; 6% in groups NaHCO, NaCl, and glucose, respectively. CONCLUSIONS/CLINICAL IMPORTANCE: Small-volume hypertonic NaHCOinfusions appear to have clinical advantages for the rapid resuscitation of hyperkalemic diarrheic calves, compared to hypertonic NaCl or glucose solutions.