Peer-reviewed veterinary case report
Effect of ripasudil eye injection on cat retinal blood flow
By Nakabayashi, Seigo et al.·Published in Experimental eye research·2015·Department of Ophthalmology, Japan·View original on PubMed →
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Original publication title: Effect of intravitreal Rho kinase inhibitor ripasudil (K-115) on feline retinal microcirculation.
- Species:
- cat
Plain-English summary
A study looked at how a new eye treatment called ripasudil (K-115) affects blood flow in the eyes of cats. The researchers injected different doses of ripasudil into the eyes of cats and measured the blood flow and vessel size in the retina. They found that higher doses of ripasudil significantly increased blood flow without changing the size of the blood vessels. This suggests that ripasudil could help improve blood circulation in the eyes of cats, which might be beneficial for certain eye conditions.
People also search for: cat eye treatment ripasudil · feline retinal blood flow · cat eye problems treatment
Abstract
Ripasudil (K-115) is a novel Rho kinase inhibitor with a potent intraocular pressure-lowering effect. However, it is unclear whether ripasudil affects the retinal blood flow (RBF). We investigated the effect of ripasudil on feline retinal microcirculation. Ripasudil (5 μM, 50 μM or 5 mM; n = 5 each concentration) or vehicle (PBS; n = 5) was injected intravitreally. The vessel diameter (D) and blood velocity (V) were measured by laser Doppler velocimetry simultaneously in the first-order retinal arterioles and the RBF was calculated. The measurements started 5 min before the injection and were performed every 10 min for 120 min. After the intravitreal injection, the retinal circulatory parameters did not change significantly in PBS or 5 μM of ripasudil. The blood V and RBF increased significantly compared to baseline, whereas the vessel D did not change significantly in 50 μM and 5 mM of ripasudil. The V in 50 μM, and the V and RBF in 5 mM of ripasudil significantly increased compared to those in PBS. Intravitreal administration of ripasudil increased the blood V and RBF in cats, suggesting that ripasudil has the potential to improve the retinal blood flow.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26197413/