Peer-reviewed veterinary case report
Irbesartan reduces atrial fibrosis and fibrillation in dogs
By Kataoka, Naoya et al.·Published in Heart and vessels·2016·Second Department of Internal Medicine, Japan·View original on PubMed →
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Original publication title: Effect of irbesartan on development of atrial fibrosis and atrial fibrillation in a canine atrial tachycardia model with left ventricular dysfunction, association with p53.
- Species:
- dog
Plain-English summary
A group of beagles with heart problems developed atrial fibrillation (AF) after being subjected to rapid heart pacing for four weeks. The dogs were divided into two groups: one received a placebo, while the other was treated with irbesartan, a medication that blocks certain receptors in the heart. The dogs treated with irbesartan showed less severe heart issues, including reduced AF duration and less fibrous tissue in the heart compared to those that did not receive the medication. This suggests that irbesartan can help protect against heart damage and AF in dogs with certain heart conditions.
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Abstract
Effects of an angiotensin II receptor blocker, irbesartan (IRB), on the development of atrial fibrosis and atrial fibrillation (AF) were assessed in a canine model of atrial tachycardia remodeling (ATR) with left ventricular dysfunction, together with its possible association with involvement of p53. Atrial tachypacing (400 bpm for 4 weeks) was used to induce ATR in beagles treated with placebo (ATR-dogs, n = 6) or irbesartan (IRB-dogs, n = 5). Non-paced sham dogs served as control (Control-dogs, n = 4). ATR- and IRB-dogs developed tachycardia-induced left ventricular dysfunction. Atrial effective refractory period (AERP) shortened (83 ± 5 ms, p < 0.05), inter-atrial conduction time prolonged (72 ± 2 ms, p < 0.05), and AF duration increased (29 ± 5 s, p < 0.05 vs. baseline) after 4 weeks in ATR-dogs. ATR-dogs also had a larger area of atrial fibrous tissue (5.2 ± 0.5 %, p < 0.05 vs. Control). All these changes, except for AERP, were attenuated in IRB-dogs (92 ± 3 ms, 56 ± 3 ms, 9 ± 5 s, and 2.5 ± 0.7 %, respectively; p < 0.05 vs. ATR for each). In ATR-dogs, p53 expression in the left atrium decreased by 42 % compared with Control-dogs (p < 0.05); however, it was highly expressed in IRB-dogs (+89 % vs. ATR). Transforming growth factor (TGF)-β1 expression was enhanced in ATR-dogs (p < 0.05 vs. Control) but reduced in IRB-dogs (p < 0.05 vs. ATR). Irbesartan suppresses atrial fibrosis and AF development in a canine ATR model with left ventricular dysfunction in association with p53.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27236656/