Peer-reviewed veterinary case report
Local clinoptilolite effects on dog gum inflammation and blood tests
By Kurtdede, Efe et al.·Published in Journal of veterinary dentistry·2026·Veterinary Faculty·View original on PubMed →
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Original publication title: Effect of Local Clinoptilolite Application on Inflammatory, Oxidative Stress and Biochemical Parameters in Gingival Crevicular Fluid and Blood in Periodontal Tissue Inflammation in Dogs.
- Species:
- dog
Plain-English summary
A group of dogs with gum disease (periodontal tissue inflammation) was treated with different combinations of medications, including a common antibiotic (amoxicillin-clavulanic acid) and a natural mineral (clinoptilolite). The dogs receiving the combination of the antibiotic and clinoptilolite showed the best improvement in their gum health and overall inflammation levels. Over a week, their blood tests indicated significant reductions in harmful markers associated with inflammation and oxidative stress. This suggests that using both treatments together can be more effective for dogs suffering from gum disease.
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Abstract
In this study, the changes caused by local and systemic inflammatory and immunological reactions and oxidative stress in the levels of some biomarkers and parameters in the gingival crevicular fluid (GCF) and blood in dogs with periodontal tissue inflammation were investigated. Fifty dogs were randomly assigned into five equal groups: 1. healthy control (NC); 2. local clinoptilolite applied during treatment (C); 3. amoxicillin-clavulanic acid, clinoptilolite and chlorhexidine used together during treatment (ACC); 4. amoxicillin-clavulanic acid and clinoptilolite applied together during treatment (AC); and 5. amoxicillin-clavulanic acid used during treatment (A). The results showed the increase in the total antioxidant capacity measurement level was significant between days 0 and 7 in all groups except NC. The decrease in the total antioxidant status (TOS) level between days 0 and 7 was found to be significant in all groups. The decrease in the malondialdehyde (MDA) level was significant between days 0 and 7 in all groups except NC. It was observed that the interleukin-1(IL-1B) level between days 0 and 7 showed a substantial decrease in the ACC and AC groups and that the matrix metalloproteinases-9 (MMP-9) and osteocalcin levels decreased significantly between days 0 and 7 in the C and AC groups. In evaluating the treatment used in this study, it was concluded that applying amoxicillin-clavulanic acid and clinoptilolite in dogs with periodontal tissue inflammation was more successful than other treatment protocols.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41021549/