Peer-reviewed veterinary case report
Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus alpha-hemolysin.
- Journal:
- Polish journal of veterinary sciences
- Year:
- 2018
- Authors:
- Feng, F et al.
- Affiliation:
- Department of College of Life Science · China
Abstract
Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30450884/