Peer-reviewed veterinary case report
Does gabapentin reduce anesthesia needs in cats?
By Chen, Hangbin et al.·Published in Frontiers in veterinary science·2023·Department of Veterinary Clinical Sciences, China·View original on PubMed →
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Original publication title: Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats.
- Species:
- cat
Plain-English summary
A group of six healthy adult cats were given either oral gabapentin or a placebo two hours before anesthesia to see if it would lower the amount of isoflurane (a common anesthetic) needed during surgery. The results showed that the cats that received gabapentin required significantly less isoflurane to not respond to a painful stimulus compared to those that received the placebo. While gabapentin helped reduce the anesthetic needed, it did not affect the cats' heart rates or other vital signs. This suggests that gabapentin can be useful for reducing the amount of anesthesia required in cats during procedures.
People also search for: cat anesthesia gabapentin · how much isoflurane for cats · effects of gabapentin on cat surgery
Abstract
OBJECTIVE: To determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats. STUDY DESIGN: Prospective, randomized, blinded, crossover, and experimental study. ANIMALS: A total of six healthy adult cats (three male, three female) aged 18-42 months, weighing 3.31 ± 0.26 kg. METHODS: Cats were randomly given oral gabapentin (100 mg cat) or placebo 2 h before starting MAC determination, with the crossover treatment given at least 7 days apart. Anesthesia was induced and maintained with isoflurane in oxygen. Isoflurane MAC was determined in duplicate using an iterative bracketing technique and tail clamp method. Hemodynamic and other vital variables were recorded at each stable isoflurane concentration and were compared between gabapentin and placebo treatments at lowest end-tidal isoflurane concentration when cats did not respond to tail clamping. A paired-test was used to compare normally distributed data, and a Wilcoxon signed-rank test was applied for non-normally distributed data. Significance was set at< 0.05. Data are mean ± standard deviation. RESULTS: Isoflurane MAC in the gabapentin treatment was 1.02 ± 0.11%, which was significantly lower than that in the placebo treatment (1.49 ± 0.12%;< 0.001), decreasing by 31.58 ± 6.94%. No significant differences were found in cardiovascular and other vital variables between treatments. CONCLUSION AND CLINICAL RELEVANCE: Oral administration of gabapentin 2 h before starting MAC determination had a significant isoflurane MAC-sparing effect in cats with no observed hemodynamic benefit.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36865443/