Peer-reviewed veterinary case report
Effect of orally administered Lactobacillus brevis HY7401 in a food allergy mouse model.
- Journal:
- Journal of microbiology and biotechnology
- Year:
- 2013
- Authors:
- Lee, Jeongmin et al.
- Affiliation:
- College of Veterinary Medicine · South Korea
- Species:
- rodent
Abstract
We had found that orally administered Lactobacillus species were effective immune modulators in ovalbumin (OVA)-sensitized mice. To validate these findings, we investigated the effects of orally administered Lactobacillus brevis HY7401 in OVA-T cell receptor transgenic mice. This strain showed a tendency to induce Th1 cytokines and inhibit Th2 cytokines. All assayed isotypes of OVA-specific antibody were effectively reduced. Systemic anaphylaxis was also relatively reduced with the probiotic administration. These results reveal that L. brevis HY7401 might be useful to promote anti-allergic processes through oral administration.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23985541/