Peer-reviewed veterinary case report
How heart disease affects adiponectin levels in dogs
By Damoiseaux, C et al.·Published in Journal of veterinary internal medicine·2014·Department of Small Animal Clinical Sciences·View original on PubMed →
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Original publication title: Effect of physiological determinants and cardiac disease on plasma adiponectin concentrations in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with heart disease, including those with dilated cardiomyopathy (DCM) and myxomatous mitral valve disease (MMVD), had their blood tested for a hormone called adiponectin. The study found that older dogs and neutered dogs had lower levels of this hormone. Interestingly, dogs with DCM had higher adiponectin levels compared to healthy dogs and those with MMVD. This suggests that adiponectin might play a role in heart disease, but more research is needed to understand its impact on health outcomes in dogs with these conditions.
People also search for: dog heart disease symptoms · dilated cardiomyopathy treatment in dogs · why is my dog’s blood test showing low adiponectin
Abstract
BACKGROUND: In humans, a high concentration of adiponectin is associated with a favorable cardiovascular risk profile whereas, in patients with heart failure (HF), a high concentration of adiponectin is associated with a less favorable prognosis. HYPOTHESIS/OBJECTIVES: To evaluate the physiological determinants of plasma adiponectin concentration in dogs and the influence of heart disease, myxomatous mitral valve disease (MMVD), and dilated cardiomyopathy (DCM). ANIMALS: One hundred and fourteen client-owned dogs and 9 Beagles from the research colony of the Clinical Veterinary Unit of the University of Liège. METHODS: We prospectively measured circulating adiponectin concentration in healthy control dogs (n = 77), dogs with MMVD (n = 22) and dogs with DCM (n = 15) of various degrees of severity. Diagnosis was confirmed by Doppler echocardiography. Plasma adiponectin concentration was measured by a canine-specific sandwich ELISA kit. RESULTS: An analysis of covariance showed an association between adiponectin concentration and age, neuter status, and heart disease. No association between adiponectin concentration and class of HF, sex, body condition score, body weight, circadian rhythm, or feeding was found. Plasma adiponectin concentration was negatively correlated with age (P = .001). Adiponectin was lower in neutered (P = .008) compared to intact dogs. Circulating adiponectin concentration was increased in dogs with DCM compared to healthy dogs (P = .018) and to dogs with MMVD (P = .014). CONCLUSIONS AND CLINICAL IMPORTANCE: Age and neutering negatively influence circulating adiponectin concentration. Plasma adiponectin concentration increased in dogs with DCM. Additional research is required to investigate if this hormone is implicated in the pathophysiology of DCM and associated with clinical outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25311942/