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Peer-reviewed veterinary case report

Tepoxalin before surgery does not harm blood clotting or liver

By Kay-Mugford, Patricia A et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2004·Schering-Plough Animal Health, United States·View original on PubMed

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Original publication title: Effect of preoperative administration of tepoxalin on hemostasis and hepatic and renal function in dogs.

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dog
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Plain-English summary

A group of young, healthy dogs were given a single dose of tepoxalin, a pain relief medication, before undergoing surgery to see if it affected their blood clotting or kidney and liver function. The results showed that tepoxalin did not have any negative impact on these important functions during the surgical process. This suggests that tepoxalin can be safely used for pain management in dogs before surgery without worrying about harming their organs or blood clotting ability.

People also search for: dog surgery pain relief · tepoxalin for dogs · preoperative medication effects in dogs

Abstract

Preemptive analgesia is an important part of surgical management, but some NSAIDs can adversely affect platelet function or renal or hepatic status. Tepoxalin is approved in the United States for control of pain and inflammation associated with arthritis and in Europe for relief of pain caused by musculoskeletal disorders. In this study, no significant effects on indices of hemostasis or renal or hepatic function were detected when a single preoperative oral dose of tepoxalin was administered to young healthy dogs undergoing anesthesia and surgery.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15468009/