Peer-reviewed veterinary case report
Recombinant distemper vaccine boosts antibodies more in previously
By Larson, L J et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2006·Department of Pathobiological Sciences, United States·View original on PubMed →
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Original publication title: Effect of recombinant canine distemper vaccine on antibody titers in previously vaccinated dogs.
- Species:
- dog
Plain-English summary
A group of previously vaccinated dogs received either a modified-live virus (MLV) vaccine or a recombinant canine distemper vaccine (Recombitek) to see which one boosted their immunity better. The dogs that got the Recombitek vaccine showed a much stronger increase in their antibody levels compared to those that received the MLV vaccine. This means that using the Recombitek vaccine can be a more effective way to enhance protection against canine distemper in dogs that have already been vaccinated.
People also search for: dog distemper vaccine effectiveness · Recombitek vaccine for dogs · boosting dog immunity after vaccination
Abstract
Two canine distemper virus (CDV) vaccine types are currently commercially available: modified-live virus (MLV) vaccines and a canarypox recombinant CDV (rCDV) vaccine (Recombitek, Merial). This study compared the ability of the rCDV vaccine and MLV vaccines to significantly enhance (boost) the antibody response of previously immunized adult and juvenile dogs. A significant (fourfold or greater) increase in titer occurred in significantly more dogs revaccinated with Recombitek C-4 or Recombitek C-6 than with the MLV-CDV vaccines. This study demonstrates that Recombitek, the only vaccine for dogs containing rCDV, is more likely to significantly boost the CDV antibody response in previously vaccinated dogs than are the MLV-CDV vaccines. Because rCDV vaccine can boost the antibody titer of dogs previously vaccinated with an MLV vaccine, it can and should be used when core vaccines are readministered.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16871492/