Peer-reviewed veterinary case report
Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice.
- Journal:
- Immunopharmacology and immunotoxicology
- Year:
- 2013
- Authors:
- Zhou, Hui et al.
- Affiliation:
- Institute of Frontier Medical Science of Jilin University · China
- Species:
- rodent
Abstract
The aim of the study is to investigate the effect of recombinant Ganoderma lucidum immunoregulatory protein (rLZ-8) on mouse models of cyclophosphamide-induced leukopenia, which we have established with both single-phase and multi-phase administration methods. Treatment with rLZ-8 had a strong effect on both models of cyclophosphamide-induced leukopenia. In particular, it increased the number of neutrophils, lymphocytes and monocytes. rLZ-8 treatment also increased the percentage of CD4(+) T cells and the levels of secreted IL-3 and IL-4, which contributed to the cyclophosphamide-induced immune dysfunction and immune system imbalance. In conclusion, rLZ-8 treatment benefitted mice with cyclophosphamide-induced leukopenia by improving overall immune function and by specifically increasing the number of white blood cells.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23656432/