Peer-reviewed veterinary case report
Does refrigerating Cerenia reduce injection pain in pets
By Narishetty, Sunil Thomas et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2009·Pfizer Animal Health, United States·View original on PubMed →
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Original publication title: Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection.
Plain-English summary
A study found that a common anti-nausea medication for dogs, Cerenia (maropitant), can cause pain when injected, especially if the medication is warm. When Cerenia is refrigerated before use, it may help reduce or even eliminate the pain associated with the injection. This means that if your dog needs this medication, asking your vet to use refrigerated Cerenia could make the experience more comfortable for your pet.
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Abstract
Injection pain has been associated with veterinary use of the antiemetic maropitant (Cerenia, Pfizer Animal Health). Cerenia is formulated using sulphobutylether-beta-cyclodextrin to bind maropitant and mitigate injection pain. The objective of this study was to determine whether the temperature of Cerenia alters binding between maropitant and sulphobutylether-beta-cyclodextrin and affects injection pain. Binding decreased as temperature increased, and Cerenia-elicited injection pain increased at warmer drug temperatures. These data suggest that the amount of free unbound maropitant increases with temperature and that injection pain increases with temperature in a similar fashion. Clinically, these studies suggest that injection of refrigerated Cerenia may significantly reduce or eliminate pain associated with SC injection of Cerenia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20037963/