Peer-reviewed veterinary case report
Resveratrol effects on fat metabolism in healthy and obese cats
By Yun, Jung Eun et al.·Published in Frontiers in veterinary science·2025·Momo Group Inc, South Korea·View original on PubMed →
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Original publication title: Effect of resveratrol supplementation on lipid metabolism in healthy and obese cats.
- Species:
- cat
Plain-English summary
A study looked at how resveratrol, a natural supplement, affects fat metabolism in healthy and overweight cats. Over four weeks, cats received either a low or high dose of resveratrol, but their weight and insulin levels didn't change. However, the cats that were overweight showed improvements in certain blood markers related to fat and inflammation, suggesting that resveratrol might help with obesity and related issues. This could be a beneficial dietary option for cats struggling with weight problems.
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Abstract
INTRODUCTION: The prevalence of lipid metabolism disorders, including obesity, increases with age in cats and humans. Obesity is a condition characterized by systemic low-grade inflammation and oxidative stress caused by excessive visceral fat accumulation. Resveratrol (RSV), a natural plant polyphenol, modulates the expression of anti-inflammatory factors. This study aimed to investigate the effects of resveratrol supplementation on lipid metabolism in both healthy and obese cats and assess its potential as a dietary supplement for improving lipid metabolism disorders in this population. METHODS: Plasma metabolite and hormone concentrations, and enzyme activities were measured in healthy, obese, and overweight cats supplemented with RSV for 4 weeks. RVS was supplemented at 1 mg/kg body weight/day (low dose) and 5 mg/kg/day (high dose) in capsules for 4 weeks. RESULTS: Body weight, body condition score, BUN, and insulin concentrations did not change in obese or overweight cats with RSV supplementation for 4 weeks. Plasma triglyceride, free fatty acids, and serum amyloid A (SAA) concentrations and lactate dehydrogenase (LDH) activities decreased, and adiponectin concentrations increased markedly in obese and overweight cats after RSV supplementation. DISCUSSION: Decreased plasma SAA concentrations and LDH activities and increased plasma adiponectin concentrations in obese and overweight cats seem to be induced by the improvement in liver function and the anti-inflammatory effect of RSV. Moreover, RSV supplementation may be useful in treating lipid metabolism disorders, including obesity, in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40308696/