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Peer-reviewed veterinary case report

Effect of sex hormones on crystal formation in a stone-forming rat model.

Journal:
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
Year:
2011
Authors:
Yoshioka, Iwao et al.
Affiliation:
Osaka University Graduate School of Medicine · Japan
Species:
rodent

Abstract

Sex hormones have substantial effects on crystal formation in the rat kidney through oxalate metabolism and oxidative cell damage. Testosterone is a promoter and estradiol an inhibitor of such crystal formation. The development of new medications related to sex hormones or GO are anticipated for sufferers of recurrent urolithiasis.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/21585166/