Peer-reviewed veterinary case report
How sucralfate affects stomach lining in stressed dogs
By Hill, Tracy L et al.·Published in Journal of veterinary internal medicine·2018·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs had their stomach lining tested to see how well it could recover from acid damage. Researchers found that applying a medication called sucralfate helped speed up the healing process of the stomach lining after it was injured. This suggests that sucralfate could be useful for treating or preventing stomach problems related to stress in dogs. If your dog is experiencing stomach issues, talk to your vet about whether sucralfate might be a good option.
People also search for: dog stomach problems treatment · sucralfate for dogs · stress-related stomach issues in dogs
Abstract
BACKGROUND: Sucralfate is a gastroprotectant with no known systemic effects. The efficacy of sucralfate for prevention and treatment of stress-related mucosal diseases (SRMD) in dogs is unknown. HYPOTHESIS/OBJECTIVES: To develop a canine ex vivo model of SRMD and to determine the effect of sucralfate on mucosal barrier function in this model. ANIMALS: Gastric antral mucosa was collected immediately postmortem from 29 random-source apparently healthy dogs euthanized at a local animal control facility. METHODS: Randomized experimental trial. Sucralfate (100 mg/mL) was applied to ex vivo canine gastric mucosa concurrent with and after acid injury. Barrier function was assessed by measurement of transepithelial electrical resistance (TER) and radiolabeled mannitol flux. RESULTS: Application of acidified Ringers solution to the mucosal side of gastric antrum caused a reduction in gastric barrier function, and washout of acidified Ringers solution allowed recovery of barrier function (TER: 34.0 ± 2.8% of control at maximum injury, 71.3 ± 5.5% at recovery, P < .001). Sucralfate application at the time of injury or after injury significantly hastened recovery of barrier function (TER: 118.0 ± 15.2% of control at maximum injury, P < .001 and 111.0 ± 15.5% at recovery, P = .35). CONCLUSIONS AND CLINICAL IMPORTANCE: Sucralfate appeared effective at restoring defects in gastric barrier function induced by acid and accelerating repair of tissues subjected to acid in this model, suggesting that sucralfate could have utility for the treatment and prevention of SRMD in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29460464/