Peer-reviewed veterinary case report
How systemic inflammation affects prostaglandin and oxidative stress
By L KIPJEN SINGH et al.·Published in Indian Journal of Animal Sciences·2020·ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh 243 122 India, IN·View original on DOAJ →
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Original publication title: Effect of systemic inflammatory response syndrome (SIRS) on prostaglandin metabolite and oxidative stress in canine pyometra
- Species:
- dog
Plain-English summary
A group of female dogs with pyometra (a serious infection of the uterus) were studied to see how it affected their overall health, particularly when it progressed to systemic inflammatory response syndrome (SIRS). The dogs with SIRS showed signs like abnormal body temperature, rapid breathing, and high heart rates, along with changes in blood tests indicating kidney stress and inflammation. The researchers found that these dogs had higher levels of a specific chemical (PGFM) linked to inflammation. This information can help veterinarians diagnose and monitor dogs with pyometra and SIRS more effectively, emphasizing the importance of timely treatment like spaying.
People also search for: dog pyometra symptoms · female dog infection treatment · spaying dog pyometra recovery
Abstract
Pyometra, either open or closed cervix, inevitably progresses to systemic inflammatory response syndrome (SIRS), if ovariohysterectomy is not done timely. The aim of the study was to investigate the effect of pyometra led SIRS on certain serum biochemical and prostaglandin metabolite, 13,14-dihydro-15-keto PGF2 alpha (PGFM) and oxidative stress indices in the canine. The pyometra positive bitches were categorized as SIRS+ (n=29) and SIRS- (n =16) based on temperature (<100.5 or >102.5°F), respiration rate (>20/min), heart rate (>102/min), and total leukocytes count (<6×103 or >16×103 per μL). The SIRS+ bitches showed hypoalbuminemia, hyperglobulinemia, elevated blood urea nitrogen and creatinine, decreased super oxide dismutase (SOD) activity with moderate increase in the lipid peroxidation. Further, the SIRS+ bitches had significantly higher serum PGFM concentration (6.83±0.7 vs. 4.12±0.4 ng/mL) than SIRS- and the level was influenced by cervical patency. It was concluded that elevated serum PGFM along with hyperglobunemia, blood urea nitrogen, creatinine would be useful in diagnosis and monitoring of pyometra led SIRS in bitch.
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Search related cases →Original publication on DOAJ: https://doi.org/10.56093/ijans.v90i4.104199