Peer-reviewed veterinary case report
How tiletamine-zolazepam affects eye pressure in dogs
By Jang, Min et al.·Published in Veterinary ophthalmology·2015·Department of Veterinary Clinical Sciences, South Korea·View original on PubMed →
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Original publication title: Effect of tiletamine-zolazepam on the intraocular pressure of the dog.
- Species:
- dog
Plain-English summary
A group of six healthy dogs were given a combination of tiletamine and zolazepam (TZ) to see how it affected their eye pressure. The dogs had their eye pressure measured before and after receiving the medication, but the results showed no significant changes in eye pressure levels. This means that tiletamine-zolazepam could be a safe option for sedation or surgery in dogs that have eye problems, as it does not raise eye pressure.
People also search for: dog eye pressure medication · tiletamine zolazepam for dogs · dog sedation options for eye problems
Abstract
OBJECTIVE: To determine the effect of tiletamine-zolazepam (TZ) on canine intraocular pressure (IOP). ANIMALS STUDIED: Six healthy dogs without ocular abnormalities were used in this study. PROCEDURES: The study was carried out as a crossover experimental trial with a 7-day interval between treatments. TZ combination was administered intravenously (IV) at a dose of 5, 10, and 20 mg/kg (TZ5, TZ10, and TZ20, respectively). Following preanesthetic baseline readings of IOP, each dog received IV TZ and then the IOP values were measured every 10 min for 40 min in all treatments. RESULTS: The baseline IOP values (mean ± standard deviation) for TZ5, TZ10, and TZ20 were 12.7 ± 0.8, 14.4 ± 1.2, and 15.3 ± 1.7 mmHg, and each IOP changed to 11.1 ± 1.1, 13.1 ± 1.4 and 13.5 ± 1.7 mmHg after intravenous administration of each TZ treatment, respectively. However, there were no statistical differences between baseline and post-treatment values. CONCLUSIONS: The TZ combination had no clinically significant effect on IOP of the dog. This could be an option for induction or surgical procedures in dogs with ophthalmic problems when an increase in IOP is undesirable.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25440910/