Peer-reviewed veterinary case report
Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2024
- Authors:
- Zozulya, S A et al.
- Affiliation:
- Mental Health Research Center
- Species:
- rodent
Abstract
In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39090471/