Effect of Triethylcholine on Acetylcholine Metabolism in the Isolated Guinea-Pig Ileum

Abstract

Triethylcholine was invariably found to depress acetylcholine (ACh) release from isolated guinea pig ileum exposed to increased intraluminal pressure Two components of the triethylcholine action were observed. The first component was due to the ganglionic blocking action of triethylcholine, and the second, which could be readily antagonised by choline chloride, was regarded as the result of impaired ACh synthesis. In concentrations which reduced the ACh release as much as 70–90%, triethylcholine did not change significantly the ACh content in the ileum.