Peer-reviewed veterinary case report
Omeprazole before anesthesia and reflux in dogs
By Lotti, F et al.·Published in The Journal of small animal practice·2021·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Effect of two different pre-anaesthetic omeprazole protocols on gastroesophageal reflux incidence and pH in dogs.
- Species:
- dog
Plain-English summary
A group of 55 dogs undergoing surgery were studied to see how different doses of omeprazole, a medication that reduces stomach acid, affected gastroesophageal reflux during anesthesia. The dogs were divided into three groups: one received omeprazole once the night before surgery, another received it twice (the night before and a few hours before surgery), and a control group received no omeprazole. The results showed that while reflux occurred in a similar number of dogs across all groups, those who received omeprazole twice had less strongly acidic reflux. This suggests that the double dose of omeprazole can help reduce the acidity of reflux during anesthesia.
People also search for: dog reflux during anesthesia · omeprazole for dogs · gastroesophageal reflux in dogs
Abstract
OBJECTIVES: Gastroesophageal reflux can occur during anaesthesia and may lead to esophagitis and occasionally oesophageal stricture formation. The aim of the study is to assess two omeprazole protocols on gastroesophageal reflux incidence and pH in anaesthetised dogs. MATERIALS AND METHODS: Fifty-five dogs undergoing elective ovariectomy were randomly assigned to: omeprazole single dose 1 mg/kg orally the evening before anaesthesia (20 dogs), omeprazole two doses 1 mg/kg orally the evening and 3 hours before anaesthesia (15 dogs), and control group that did not receive omeprazole (20 dogs). An oesophageal impedance/pH probe was used to measure gastroesophageal reflux incidence and pH during anaesthesia. RESULTS: Gastroesophageal reflux was observed in 55% (11/20) of control dogs, 55% (11/20) of dogs receiving omeprazole once and 47% (7/15) of dogs receiving omeprazole twice. The incidence was not statistically significant different between groups. Gastroesophageal reflux pH (mean ± sd) was higher in dogs receiving omeprazole twice (6.3 ± 1.5), when compared to either control dogs (3.8 ± 1.1) or dogs receiving omeprazole once (4.1 ± 1.5). Strongly acidic reflux (pH < 4) was observed in 7% (1/15) of dogs receiving omeprazole twice versus 55% (11/20) and 35% (7/20) of control dogs and dogs receiving omeprazole once, respectively. CLINICAL SIGNIFICANCE: Omeprazole administered the evening and 3 hours before anaesthesia increased gastroesophageal reflux pH and decreased the incidence of strongly acidic reflux in dogs. A single dose of omeprazole given the evening before anaesthesia had no effect on reflux pH.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33769569/