Peer-reviewed veterinary case report
Effect of ultrasonic irradiation on the development of symptoms of depression and anxiety in rats.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2013
- Authors:
- Morozova, A Yu et al.
- Affiliation:
- Department of Basic and Applied Neurobiology
- Species:
- rodent
Abstract
Behavioral reactions of rats were studied under conditions of constant exposure to ultrasonic irradiation at a frequency of 20-45 kHz for 21 days. In rats subjected to ultrasound, impaired behavior in the social interest test and Porsolt forced swimming test was observed; the development of anhedonia in the sucrose preference test was revealed (manifested in the symptoms of depression). The effects of ultrasonic irradiation were abolished by an antidepressant fluoxetine, a selective serotonin reuptake inhibitor. Our results indicate that chronic exposure to ultrasonic radiation produces a modulatory effect on depressive symptoms in rats. These changes satisfy the requirements for experimental animals, which are used as a model of psychopathological processes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23658912/