Peer-reviewed veterinary case report
How losing weight lowers inflammation risk in obese dogs
By Tvarijonaviciute, Asta et al.·Published in Veterinary journal (London, England : 1997)·2012·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Effect of weight loss on inflammatory biomarkers in obese dogs.
- Species:
- dog
Plain-English summary
A group of obese dogs underwent a weight loss program that aimed for about 2.5% of their body weight to be lost each week. As they lost weight, their overall health markers improved, including better lipid levels and lower insulin-like growth factor-1, which is linked to obesity. While some inflammatory markers stayed normal, the dogs showed an increase in adiponectin, a protein that helps reduce inflammation related to obesity. This suggests that losing weight can help lower the risk of inflammation in overweight dogs.
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Abstract
The objective of this study was to evaluate the effects of weight loss on selected serum inflammatory biomarkers in obese dogs. An experimentally induced bodyweight reduction of approximately 2.5%/week was accompanied by significant decreases in metabolic markers of obesity (lipidic profile, fructosamine, and insulin-like growth factor-1). The concentrations of acute phase proteins and of selected cytokines remained within reference ranges in obese dogs during weight loss, suggesting that significant inflammation was not a major component of this experimental model. However, adiponectin concentrations increased following the period of weight loss suggesting reduced susceptibility of these animals to obesity-related inflammation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22464400/