Effect ofandon alleviating aluminum toxicity state in the albino rats.

Abstract

The study objective was to evaluatepotential andcombination's potential to reduce aluminum toxicity and return to the normal state. In the present study, a hundred albino rats were randomly divided into five equal groups. The first group was used as a control group; the other four groups were exposed to aluminum 1,600 ppm. The second exposed to aluminum only; the third and fourth groups were treated with5% and5%, respectively, while the fifth group was treated with a mix of2.5% and2.5% for 8th weeks. After 8 weeks, the aluminum administration was stopped, and the second group was divided into three groups. The groups were treated with5% and5%, and a mix of2.5% and2.5%, respectively. The first group was the control group (continued from the first experiment). Garlic andwere crushed and added to feed while receiving aluminum chloride daily at a dose of 1.6 ml/l was added to the drinking water. Histopathological changes in the liver, kidney, and testes were investigated after 8 and 16 weeks, and blood samples were collected after 4, 8, and 16 weeks for biochemical blood parameters. The results showed that the histopathological examination of the liver, kidney, and testes showed signs of congestion in blood vessels after aluminum exposure. Meanwhile, the treatment withoror the mixture between them had positive effects on evading the harmful effects of aluminum in the liver, Kidney, and testes tissues. In addition, there were protective effects forandagainst aluminum on serum creatinine, urea, ALT, and AST concentrations. The present study concluded that supplementationoror their combination could reduce aluminum toxicity and return the liver, kidney, and testes to normal.