Peer-reviewed veterinary case report
Aprotinin treatment improves survival in dogs with bile-trypsin
By Imrie, C.W. & Mackenzie, M.Ā·Published in DigestionĀ·2009Ā·View original on Crossref ā
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research ā every detail traces back to the citation above. How we work ā
Original publication title: Effective Aprotinin Therapy in Canine Experimental Bile-Trypsin Pancreatitis
- Species:
- dog
Plain-English summary
A group of dogs developed severe pancreatitis after a bile-trypsin mixture was injected, leading to high mortality rates. Four dogs that only received supportive care did not survive, while 18 others were treated with intravenous aprotinin, a medication that helps reduce inflammation. Those who started treatment within 1 to 6 hours after the pancreatitis began had a much better chance of survival, with no significant health issues afterward. However, delaying treatment led to higher death rates. This suggests that early intervention with aprotinin can be crucial in managing acute pancreatitis in dogs.
People also search for: dog pancreatitis treatment Ā· signs of pancreatitis in dogs Ā· aprotinin for dogs pancreatitis
Abstract
Acute haemorrhagic pancreatitis was induced by intraductal injection of a bile-trypsin blood mixture in 22 dogs, with a 100% mortality in 4 dogs given supportive therapy alone. Control animals survived without ill effect. The remaining 18 dogs were given supplementary intravenous aprotinin (400,000 KI units) at varying times after onset of acute pancreatitis. 10 given this treatment starting 1ā6 h after induction of pancreatitis survived without appreciable morbidity. A 9- and 12-hour delay in starting aprotinin therapy was associated with a 25 and 75% mortality rate, respectively. Monitoring of serum (and urinary) amylase, serum calcium and albumin is documented.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases āOriginal publication on Crossref: https://doi.org/10.1159/000198592